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Commercial SMA Polymers

The discovery that copolymers composed of styrene and maleic acid groups can solubilize native lipid:protein complexes direct from cells or raw membrane has stimulated a flurry of new research.

Here we list a variety of the commercially available polymers, and can provide samples of activated forms at our workshops or on a collaborative research basis.

Product S:MA Ratio Mw (g/mol) Mn (g/mol) Source
Xiran SZ20010 4.3:1 7300 2500 Polyscope
Xiran SZ23110 3.3:1 110000 44000 Polyscope
Xiran SZ25010 * 3:1 10000 4000 Polyscope
Xiran SZ26080 2.8:1 80000 32000 Polyscope
Xiran SZ26120 2.8:1 120000 48000 Polyscope
Xiran SZ28110 2.6:1 110000 44000 Polyscope
Xiran SZ28130 2.6:1 130000 n/a Polyscope
Xiran SZ30010 * 2.3:1 6500 2500 Polyscope
Xiran SZ33030 2:1 30000 9000 Polyscope
Xiran SZ40005 * 1.2:1 5000 2000 Polyscope
SMA1000 1:1 5500 2000 Cray Valley
SMA2000 2:1 7500 3000 Cray Valley
SMA2021 2:1 21000 12000 Cray Valley
SMA3000 3:1 9500 3800 Cray Valley
SMA4000 4:1 n/a 3800 Cray Valley
Lipodisq L8920 2:1 n/a n/a Sigma
Lipodisq L9045 3:1 n/a n/a Sigma
Lipodisq L9170 3:1 n/a n/a Sigma
Sokalan CP9 n/a 12000 n/a BASF

*Contact us for free samples of SZ25010, SZ30010 and SZ40005 for collaborative research, as these have now been formulated as an activated set for convenient use. These have been widely used and are recommended to test and optimize purification of membrane proteins along with bound lipids and partner proteins. A ratio of styrene to maleic acid of around 2:1 is generally recommended.

†Sokalan CP9 is the tradename of an alternating copolymer of maleic acid and diisobutylene (2,4,4-trimethylpent-1-ene) (DIBMA). Sandro Keller's slides on DIBMA showing that it is well suited to solubilizing larger proteins, and is compatible with UV experiments and higher levels of divalent cations.

Note: The SMA copolymers are defined by the average ratio of styrene to maleic acid repeat units (S:MA). The lengths and blockiness of the polymers is different for each. The number average molecular weight (Mn) is total weight of the polymer molecules divided by the number of molecules. The weight average molecular weight (Mw) is more sensitive to the larger chains present. The polydispersity index (PDI) equals Mw/Mn and is a measure of distribution of the molecular weights.

We welcome you to discuss your thoughts on SMA and related polymers below.